Exploiting miRNA target repression cooperativity to fight therapy resistance in cancer

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Exploiting miRNA target repression cooperativity to fight therapy resistance in cancer

Category : Publications

Lethal outcome in tumour metastasis is associated with the acquisition of resistance to therapy. We have explored to make use of miRNA target repression cooperativity to fight therapy resistance in cancer. To this end,  we integrated bioinformatics, structural and kinetic modelling, and experiments to investigate miRNA cooperative regulation of E2F1, a transcription factor overexpresed in melanoma and other aggressive tumors.

http://www.thno.org/v08p1106


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